Benzyl isocyanate → HCID 54106829, compound

HRID 1608917Notes

Reaction equation

HRID 1608917 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([CH:12]=[CH:13][CH:14]=1)[O:6][CH2:7][CH:8]([OH:11])[CH2:9][CH3:10].[CH2:17]([N:24]=[C:25]=[O:26])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(OCC)(=O)C.C(N(CC)CC)C.CCCCCC>[F:1][C:2]([F:15])([F:16])[C:3]1[CH:4]=[C:5]([CH:12]=[CH:13][CH:14]=1)[O:6][CH2:7][CH:8]([O:11][C:25](=[O:26])[NH:24][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:9][CH3:10]

Participants

6

Reactant 2

HCID 76639Benzyl isocyanateHCID 113793022-Butanol, 1-[3-(trifluoromethyl)phenoxy]-

Product 1

HCID 54106829HCID 54106829, compound

Reagents, catalysts & solvents 3

HCID 8471TriethylamineCatalystHCID 8058HexaneSolventHCID 8857Ethyl AcetateSolvent

Procedure

4.7 g of 1-(3-trifluoromethylphenoxy)-butan-2-ol and 2.7 g of benzyl isocyanate are dissolved in 60 ml of ethyl acetate. After addition of one drop of triethylamine, the reaction mixture is allowed to stand for 20 hours at 22° C. The solvent is stripped off and the residue is stirred in n-hexane. The desired crystalline product, O--[1-(3-trifluoromethylphenoxy)-2-butyl]-N-benzylcarbamate, is obtained in a yield of 5.2 g; m.p. 73°-74° C.

Sources & evidence

ORD record
ord-bc826bfa28d6435793d174bae07e4fd6
Source dataset
uspto-grants-1995_03
Patent number
US05399545

Reaction notes

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