p-Toluenesulfonic acid → HCID 54157887, compound

HRID 1609120Notes

Reaction equation

HRID 1609120 reaction equation
C1(C)C=CC(S(O)(=O)=[O:8])=CC=1.[O:12]1[CH:17]=[CH:16][CH2:15][CH2:14][CH2:13]1.[CH3:18][N:19]([CH3:23])[CH2:20][CH2:21][OH:22].C(=O)(O)[O-].[Na+]>>[CH3:18][N:19]([CH:20]([OH:8])[CH2:21][O:22][CH:17]1[CH2:16][CH2:15][CH2:14][CH2:13][O:12]1)[CH3:23]

Participants

5

Reactant 4

HCID 6101p-Toluenesulfonic acidHCID 79022-(Dimethylamino)ethanolHCID 80803,4-dihydro-2H-pyranHCID 516892Sodium Bicarbonate

Product 1

HCID 54157887HCID 54157887, compound

Procedure

10.0 mg of paratoluenesulphonic acid, 8.7 ml of dihydropyran, then 7.12 g of N,N-dimethylethanol-amine are mixed together at 20° C. The temperature is taken to 60° C., and after agitation for 2 hours the mixture is returned to 20° C. 0.5 g of sodium bicarbonate is then added. Agitation is continued for one hour. The tetrahydropyranyloxylated derivative is obtained which is immediately reacted.

Workup

  1. customis taken to 60° C.
  2. waitAgitation is continued for one hour
  3. customThe tetrahydropyranyloxylated derivative is obtained which
  4. customis immediately reacted

Sources & evidence

ORD record
ord-69a076b67e8043d69027e8d1e83e208c
Source dataset
uspto-grants-1995_03
Patent number
US05399590

Reaction notes

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