Potassium Carbonate → HCID 20084540, compound

HRID 1609281Notes

Reaction equation

HRID 1609281 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[NH:16][C:17](=[O:25])[C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=1)#[N:2].Br[CH2:27][C:28]([O:30][CH3:31])=[O:29].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O.O>[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[NH:16][C:17]([C:18]1[CH:19]=[CH:20][C:21]([O:24][CH2:27][C:28]([O:30][CH3:31])=[O:29])=[CH:22][CH:23]=1)=[O:25])#[N:2]

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 20084520HCID 20084520, compound

Product 1

HCID 20084540HCID 20084540, compoundYield 99.3%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

In 10 ml of N,N-dimethylformamide were dissolved 1.0 g of N-[2-(2-cyanophenylthio)phenyl]-4-hydroxybenzamide and 0.49 g of methyl bromoacetate followed by addition of 0.6 g of potassium carbonate, and the mixture was stirred at room temperature for 4 hours. The reaction mixture was then diluted with water and crystals separated out therefrom were collected by filtration and washed with water and aqueous ethanol in that order to give 1.2 g of the title compound as white crystals.

Workup

  1. customseparated out
  2. filtrationtherefrom were collected by filtration
  3. washwashed with water and aqueous ethanol in that order

Sources & evidence

ORD record
ord-62dd63a74bef4b50951b5db6bc996c23
Source dataset
uspto-grants-1995_03
Patent number
US05399703

Reaction notes

Loading…