Methyl iodide → HCID 20084491, compound

HRID 1609287Notes

Reaction equation

HRID 1609287 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[S:12][C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[C:15]#[N:16])=[O:4].CI.[C:25](=O)([O-])[O-].[K+].[K+]>CN(C)C=O.O>[CH3:25][N:5]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[S:12][C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[C:15]#[N:16])[C:3](=[O:4])[C:2]([F:1])([F:21])[F:22]

Participants

6

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 20084556HCID 20084556, compound

Product 1

HCID 20084491HCID 20084491, compoundYield 95.8%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

In 20 ml of N,N-dimethylformamide was dissolved 2.8 g of 2-[2-(trifluoroacetylamino)phenylthio]benzonitrile followed by addition of 2.4 g of methyl iodide and 2.4 g of potassium carbonate, and the mixture was stirred at room temperature for 2 hours, at the end of which time the reaction mixture was diluted with water. The crystals separated out therefrom were collected by filtration, washed with water and aqueous ethanol to give 2.8 g of the title compound as white crystals.

Workup

  1. customThe crystals separated out
  2. filtrationtherefrom were collected by filtration
  3. washwashed with water and aqueous ethanol

Sources & evidence

ORD record
ord-760c277c26a04ae08c56ace8aa2d081c
Source dataset
uspto-grants-1995_03
Patent number
US05399703

Reaction notes

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