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HRID16094

反应详情

EQUATION

反应方程式

HRID 16094 的结构方程式

REACTANTS

反应物

4
结构：O
HCID962

Water

H2O

结构：CCOC(=O)CBr
HCID7748

Ethyl bromoacetate

C4H7BrO2

结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：O=C(c1ccc(-c2cc(Cl)ccc2O)cc1F)N1CCCC1
HCID67276502

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)COc1ccc(Cl)cc1-c1ccc(C(=O)N2CCCC2)c(F)c1
HCID131728177

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

The product of step c) (0.11 g) was dissolved in DMF (5 ml), ethylbromoacetate (0.04 ml) and potassium carbonate (0.1 g) were added. The reaction mixture was stirred for 16 h at RT. Water and ethyl acetate were added. The organic layer was removed, dried (MgSO4) and evaporated in vacuo. The residue was purified by flash column chromatography eluting with isohexane:ethyl acetate (1:1) to give the sub-title compound. Yield 0.12 g.

WORKUP

后处理

  1. customThe organic layer was removed
  2. dry with materialdried (MgSO4)
  3. customevaporated in vacuo
  4. customThe residue was purified by flash column chromatography
  5. washeluting with isohexane:ethyl acetate (1:1)