Dimethylformamide → 4-chloro-N-({4-chloro-3-[(3-chloro-5-cyclopropylphenyl)oxy]-2-fluorophenyl}methyl)-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazole-5-carboxamide

HRID 160947Notes

Reaction equation

HRID 160947 reaction equation
[CH3:77][CH2:78][O:79][C:80]([CH3:81])=[O:82].[CH:63]([N:64]([CH:65]([CH3:66])[CH3:67])[CH2:68][CH3:69])([CH3:70])[CH3:71].[Cl:1][c:2]1[c:3]([O:11][c:12]2[cH:13][c:14]([Cl:21])[cH:15][c:16]([CH:18]3[CH2:19][CH2:20]3)[cH:17]2)[c:4]([F:10])[c:5]([CH2:8][NH2:9])[cH:6][cH:7]1.[Cl:22][c:23]1[n:24][cH:25][n:26]([CH2:31][O:32][CH2:33][CH2:34][Si:35]([CH3:36])([CH3:37])[CH3:38])[c:27]1[C:28](=[O:29])[OH:30].[O:72]=[CH:73][N:74]([CH3:75])[CH3:76].[P-:39]([F:40])([F:41])([F:42])([F:43])([F:44])[F:45].[n:46]1([O:47][C:48]([N:49]([CH3:50])[CH3:51])=[N+:52]([CH3:53])[CH3:54])[c:55]2[n:56][cH:57][cH:58][cH:59][c:60]2[n:61][n:62]1>>[Cl:1][c:2]1[c:3]([O:11][c:12]2[cH:13][c:14]([Cl:21])[cH:15][c:16]([CH:18]3[CH2:19][CH2:20]3)[cH:17]2)[c:4]([F:10])[c:5]([CH2:8][NH:9][C:28]([c:27]2[c:23]([Cl:22])[n:24][cH:25][n:26]2[CH2:31][O:32][CH2:33][CH2:34][Si:35]([CH3:36])([CH3:37])[CH3:38])=[O:29])[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 68485496({4-Chloro-3-[(3-chloro-5-cyclopropylphenyl)oxy]-2-fluorophenyl}methyl)amineHCID 684855334-chloro-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazole-5-carboxylic acid

Product 1

HCID 684809964-chloro-N-({4-chloro-3-[(3-chloro-5-cyclopropylphenyl)oxy]-2-fluorophenyl}methyl)-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazole-5-carboxamide

Sources & evidence

ORD record
ord-0cd14fd530c84d85a4a64173303d128d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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