Ethanol → N-[7-(4-Fluoro-phenyl)-4-methoxy-benzooxazol-2-yl]-2-methoxymethyl-isonicotinamide

HRID 1611959Notes

Reaction equation

HRID 1611959 reaction equation
Cl[CH2:2][C:3]1[CH:4]=[C:5]([CH:27]=[CH:28][N:29]=1)[C:6]([NH:8][C:9]1[O:10][C:11]2[C:17]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)=[CH:16][CH:15]=[C:14]([O:25][CH3:26])[C:12]=2[N:13]=1)=[O:7].[H-].[Na+].[CH2:32]([OH:34])C>O1CCOCC1.CN(C=O)C>[F:24][C:21]1[CH:22]=[CH:23][C:18]([C:17]2[C:11]3[O:10][C:9]([NH:8][C:6](=[O:7])[C:5]4[CH:27]=[CH:28][N:29]=[C:3]([CH2:2][O:34][CH3:32])[CH:4]=4)=[N:13][C:12]=3[C:14]([O:25][CH3:26])=[CH:15][CH:16]=2)=[CH:19][CH:20]=1

Participants

6

Reactant 3

HCID 702EthanolHCID 24758Sodium hydrideHCID 100930682-Chloromethyl-N-[7-(4-fluoro-phenyl)-4-methoxy-benzooxazol-2-yl]-isonicotinamide

Product 1

HCID 10319211N-[7-(4-Fluoro-phenyl)-4-methoxy-benzooxazol-2-yl]-2-methoxymethyl-isonicotinamide

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 312751,4-DioxaneSolvent

Procedure

From 2-chloromethyl-N-[7-(4-fluoro-phenyl)-4-methoxy-benzooxazol-2-yl]-isonicotinamide with sodium hydride and ethanol in dioxane and DMF. ES-MS m/e (%): 408 (M+H+, 100).

Sources & evidence

ORD record
ord-257488e6c55f462ea69742a3b711f9b1
Source dataset
uspto-grants-2006_01
Patent number
US06992083B2

Reaction notes

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