4-Nitrophenol → HCID 19776198, compound

HRID 1612602Notes

Reaction equation

HRID 1612602 reaction equation
[CH:1]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][CH:4]=[C:3]([OH:10])[CH:2]=1.[I:11][C:12]1[CH:20]=[CH:19][C:15]([C:16](Cl)=[O:17])=[CH:14][CH:13]=1.C(N(CC)CC)C>C1COCC1>[I:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([O:10][C:3]2[CH:4]=[CH:5][C:6]([N+:7]([O-:9])=[O:8])=[CH:1][CH:2]=2)=[O:17])=[CH:14][CH:13]=1

Participants

5

Reactant 3

HCID 9804-NitrophenolHCID 8471TriethylamineHCID 743734-Iodobenzoyl chloride

Product 1

HCID 19776198HCID 19776198, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2 mM of p-nitrophenol are reacted overnight with 2 mM of p-iodo benzoic acid chloride in the presence of 2 mM of triethylamine in 20 ml of THF. The solvent is evaporated and the residue is taken up in chloroform and washed with 1N HCl, then with water. The solution is dried over MgSO4. It is purified on a chromatography column (silica; eluant CHCl3 -hexane 85/15 v/v). Yield: 90%.

Workup

  1. customThe solvent is evaporated
  2. washwashed with 1N HCl
  3. dry with materialThe solution is dried over MgSO4
  4. customIt is purified on a chromatography column (silica; eluant CHCl3 -hexane 85/15 v/v)

Sources & evidence

ORD record
ord-ab026a93b0974be495a279fbe0b052bd
Source dataset
uspto-grants-1993_03
Patent number
US05190741

Reaction notes

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