反应详情

温度

95 °C

A suspension of 60% sodium hydride/oil dispersion (1.00 g, 25 mmol) in anhydrous dimethylformamide (40 ml) under nitrogen was treated with 4-amino-5-chloro-2-hydroxybenzoic acid methyl ester (4.03 g, 20 mmol), stirred for 30 minutes, then treated with 2-bromoethyl methyl ether (3.48 g, 25 mmol). The mixture was heated to 95±5° C. for 1.5 hours, then cooled and added to water (250 mL). The aqueous suspension was filtered, and the solid was washed with water, air dried, collected, and recrystallized from ether/hexane to afford 2.75 g (53%) of the tile compound; mp 121.0°-122.5° C.

1. temperaturecooled
2. filtrationThe aqueous suspension was filtered
3. washthe solid was washed with water, air
4. customdried
5. customcollected
6. customrecrystallized from ether/hexane