Sodium hydride → 1,2,5-Thiadiazolidine-2-carboxylic acid, 4,4-dimethyl-, 1,1-dimethylethyl ester, 1,1-dioxide

Temperature

40 °C

To a stirred solution of 3,3-dimethyl-1,2,5-thiadiazolidine-1,1-dioxide (2.5 g, 16.6 mmol) in anhydrous dimethylformamide (50 ml) was added sodium hydride (60% dispersion in oil; 666 mg) in two portions. After being stirred at 40° C. for 50 minutes under nitrogen, the mixture was allowed to cool to room temperature, diluted with anhydrous dimethylformamide (20 ml) and treated with di-tert-butyldicarbonate (3.99 g, 18.26 mmol). After 1 hour 45 minutes of stirring at room temperature, the mixture was diluted with water (200 ml) and extracted with diethyl ether (3×100 ml). The organic phases were washed with brine (2×50 ml), dried (MgSO4) and concentrated. Flash chromatography of the residue (silica gel, dichloromethane to dichloromethane-diethyl ether 50:50) gave a mixture of the required product and 2,5-di-tert-butyloxycarbonyl-3,3-dimethyl-1,2,5-thiadiazolidine-1,1-dioxide. Trituration of this mixture with hot hexane afforded 1.26 g (30%) of the required title compound as a white solid; δH (250 MHz, CDCl3) 4.39 (1H, br s, --NH--), 3.70 (2H, s, --CH2 --), 1.54 (9H, s, t-Bu), 1.47 (6H, s, --CMe2); m/z (CI) 249 (M+ -1).

1. temperatureto cool to room temperature
2. stirringAfter 1 hour 45 minutes of stirring at room temperature
3. extractionextracted with diethyl ether (3×100 ml)
4. washThe organic phases were washed with brine (2×50 ml)
5. dry with materialdried (MgSO4)
6. concentrationconcentrated
7. customFlash chromatography of the residue (silica gel, dichloromethane to dichloromethane-diethyl ether 50:50) gave

ORD record

ord-7bf24d3153794c159ca2a61b5b258f66

Source dataset

uspto-grants-1993_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05194440