Hydrochloric Acid → 3-(Pyridin-2-yl)prop-2-yn-1-ol

2-Propynyl alcohol (35 ml) was added dropwise to a stirred mixture of 2-bromopyridine (23.7 g), bis(triphenylphosphine)palladium chloride (1.54 g), triethylamine (21 ml), cuprous iodide (1.5 g) and acetonitrile (150 ml) and the mixture was stirred at ambient temperature for 30 minutes and then heated to 60° C. for 2 hours. The mixture was cooled to ambient temperature, poured into water (200 ml) and neutralised by adding dilute aqueous hydrochloric acid. The mixture was extracted with methylene chloride (2×500 ml) and the combined extracts were washed with water (500 ml), dried (MgSO4) and evaporated. The residue was purified by column chromatography eluting with a 1:1 v/v mixture of methylene chloride and ethyl acetate to give 3-(2-pyridyl)prop-2-yn-1-yl alcohol (14 g, 70%), m.p. 78°-80° C. (recrystallised from a mixture of hexane and ethyl acetate).

1. temperatureheated to 60° C. for 2 hours
2. temperatureThe mixture was cooled to ambient temperature
3. extractionThe mixture was extracted with methylene chloride (2×500 ml)
4. washthe combined extracts were washed with water (500 ml)
5. dry with materialdried (MgSO4)
6. customevaporated
7. customThe residue was purified by column chromatography
8. washeluting with a 1:1 v/v mixture of methylene chloride and ethyl acetate

ORD record

ord-8c7db5211e8e48b38c036d21a6dd90a1

Source dataset

uspto-grants-1993_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05196419