Water → HCID 59633897, compound

HRID 1615071Notes

Reaction equation

HRID 1615071 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([O:9][CH3:10])[CH:3]=1.[CH2:11]([CH:13](Cl)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)C.[C:21]([O-])([O-])=O.[K+].[K+].O>CN(C=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:21][C:17]2[CH:16]=[CH:15][C:14]([CH2:13][CH3:11])=[CH:19][CH:18]=2)=[C:4]([O:9][CH3:10])[CH:3]=1

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 2622344-Bromo-2-methoxyphenolHCID 524241(1-Chloropropyl)benzene

Product 1

HCID 59633897HCID 59633897, compoundYield 99.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of 4-bromo-2-methoxyphenol (7.0 g) and ethylbenzyl chloride (5.6 g) in DMF (35 mL) was added K2CO3 (5.7 g). The reaction mixture was stirred at 80° C. for 1 hr. Water was added to the reaction mixture. The precipitated solid was collected on a filter and dried to give the title compound (11 g, 99%).

Workup

  1. customThe precipitated solid was collected on
  2. filtrationa filter
  3. customdried

Sources & evidence

ORD record
ord-e0fc5bac5e994aa6a0278294725c99f2
Source dataset
uspto-grants-2014_07
Patent number
US08765739B2

Reaction notes

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