Chloroacetyl chloride → (5R)-5-Phenylmorpholin-3-one

To a mixture of (2R)-2-amino-2-phenyl-ethanol (10 g, 72.90 mmol) and triethylamine (18.45 g, 25.41 mL, 182.3 mmol) in THF (207.5 mL) at 0° C., was added 2-chloroacetyl chloride (8.234 g, 5.799 mL, 72.90 mmol) over 5 mins. The reaction mixture was partitioned between EtOAc (100 mL) and water (100 mL) and the organic layer separated, washed successively with water (2×100 mL), brine (1×100 mL), dried over MgSO4, filtered and concentrated in vacuo. The crude product was then dissolved in THF (145.2 mL) and NaH (60% in mineral oil) (3.499 g, 87.48 mmol) was added portionwise over 5 mins at rt. On complete addition, the resulting mixture was stirred at rt for 1.5 h. The reaction mixture was quenched with saturated aqueous ammonium chloride solution (50 mL) and diluted with EtOAc (50 mL) and the organic layer separated, washed with sequentially with water (2×50 mL) and brine (1×50 mL), dried over MgSO4, filtered and concentrated in vacuo. The crude material was purified by ISCO column companion system (330 g column, 0-10% MeOH/CH2Cl2). Product fractions were combined and concentrated in vacuo to leave the product as a pale yellow solid (5.2 g, 41% yield); 1H NMR (400.0 MHz, DMSO) d 3.55 (1H, m), 3.96 (1H, m), 4.08 (2H, s), 4.63 (1H, m), 7.29-7.40 (5H, m) and 8.46 (1H, s) ppm.

1. customThe reaction mixture was partitioned between EtOAc (100 mL) and water (100 mL)
2. customthe organic layer separated
3. washwashed successively with water (2×100 mL), brine (1×100 mL)
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated in vacuo
7. dissolutionThe crude product was then dissolved in THF (145.2 mL)
8. additionOn complete addition
9. customThe reaction mixture was quenched with saturated aqueous ammonium chloride solution (50 mL)
10. additiondiluted with EtOAc (50 mL)
11. customthe organic layer separated
12. washwashed with sequentially with water (2×50 mL) and brine (1×50 mL)
13. dry with materialdried over MgSO4
14. filtrationfiltered
15. concentrationconcentrated in vacuo
16. customThe crude material was purified by ISCO column companion system (330 g column, 0-10% MeOH/CH2Cl2)
17. concentrationconcentrated in vacuo

ORD record

ord-98b7392bcaca42acb86a814a1d026f4b

Source dataset

uspto-grants-2014_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08765751B2