Dimethylformamide → HCID 86667820, compound

HRID 1615692Notes

Reaction equation

HRID 1615692 reaction equation
[CH3:1][C:2]1[N:7]2[N:8]=[C:9]([CH:11]([CH3:16])[CH2:12][C:13](O)=[O:14])[N:10]=[C:6]2[C:5]([CH3:17])=[N:4][CH:3]=1.C(Cl)(=O)C([Cl:21])=O.CN(C=O)C>C(Cl)Cl>[CH3:1][C:2]1[N:7]2[N:8]=[C:9]([CH:11]([CH3:16])[CH2:12][C:13]([Cl:21])=[O:14])[N:10]=[C:6]2[C:5]([CH3:17])=[N:4][CH:3]=1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 68089388HCID 68089388, compound

Product 1

HCID 86667820HCID 86667820, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 3-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)butanoic acid (200 mg, 0.086 mmol) in DCM (15 mL) was added oxalyl chloride (3 mL) and DMF (0.1 mL). The mixture was stirred at room temperature for 2 h. The mixture was then evaporated under reduced pressure to give the product as a brown solid (208 mg, 96% yield).

Workup

  1. customThe mixture was then evaporated under reduced pressure

Sources & evidence

ORD record
ord-16c51014509141acaa07677d717f2074
Source dataset
uspto-grants-2014_07
Patent number
US08765760B2

Reaction notes

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