反应详情

0.235 g (0.50 mmol) tert-butyl (R)-3-(3,5-difluoro-phenyl)-4-methoxycarbonylmethyl-5-oxo-8,11-dioxa-1,4-diaza-spiro[5.6]dodecane-1-carboxylate, 5 ml THF, 1 ml of water and 13.2 mg (0.55 mmol) lithium hydroxide were stirred for 2 h at RT. Then the mixture was adjusted to pH7 with a 0.1N hydrochloric acid. The reaction mixture was evaporated to dryness by rotary evaporation.

1. customThe reaction mixture was evaporated to dryness by rotary evaporation