Lithium Hydroxide → HCID 68154442, compound

HRID 1615741Notes

Reaction equation

HRID 1615741 reaction equation
[OH-].[Li+].[C:3]([O:7][C:8]([N:10]1[CH2:15][CH:14]([C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[C:18]([F:23])[CH:17]=2)[N:13]([CH2:24][C:25]([O:27]C)=[O:26])[C:12](=[O:29])[C@@H:11]1[CH2:30][CH:31]1[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1)=[O:9])([CH3:6])([CH3:5])[CH3:4]>O.C1COCC1>[C:3]([O:7][C:8]([N:10]1[CH2:15][CH:14]([C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[C:18]([F:23])[CH:17]=2)[N:13]([CH2:24][C:25]([OH:27])=[O:26])[C:12](=[O:29])[C@@H:11]1[CH2:30][CH:31]1[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37]1)=[O:9])([CH3:6])([CH3:4])[CH3:5]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 68154739HCID 68154739, compound

Product 1

HCID 68154442HCID 68154442, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

10 mg (0.42 mmol) lithium hydroxide in 800 μl water were added to 105 mg (0.21 mmol) (2S)-tert-butyl-2-(cycloheptylmethyl)-5-(3,5-difluorophenyl)-4-(2-methoxy-2-oxoethyl)-3-oxopiperazine-1-carboxylate in 2 ml THF. After 2 h tetrahydrofuran was distilled off and the aqueous solution was neutralised with hydrochloric acid. The aqueous phase was extracted with ethyl acetate. The ethyl acetate phase was dried and evaporated down.

Workup

  1. distillationAfter 2 h tetrahydrofuran was distilled off
  2. extractionThe aqueous phase was extracted with ethyl acetate
  3. dry with materialThe ethyl acetate phase was dried
  4. customevaporated down

Sources & evidence

ORD record
ord-79add2bca8fc481482243b8de6569dba
Source dataset
uspto-grants-2014_07
Patent number
US08765763B2

Reaction notes

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