反应详情

28 mg (0.66 mmol) sodium hydride were added to 0.23 g (0.6 mmol) tert-butyl-3-(4-fluorophenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecane-1-carboxylate in 5 ml DMF. After 5 min at RT 64 μl (0.91 mmol) methyl bromoacetate were added dropwise and then the reaction mixture was stirred for 1 h at RT. The reaction was poured onto ice water and extracted with ethyl acetate. The organic phase was washed with water, dried and evaporated down.

1. additionThe reaction was poured onto ice water
2. extractionextracted with ethyl acetate
3. washThe organic phase was washed with water
4. customdried
5. customevaporated down