反应详情

温度

-78 °C

30 g (106 mmol) of 3-bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-1-ol are dissolved in 500 mL of anhydrous THF. The medium is cooled to −78° C. and 156 mL (265 mmol) of tert-butyllithium are then added dropwise. After 45 minutes at this temperature, 12.3 mL (159 mmol) of dimethylformamide are added. The mixture is warmed to room temperature and then treated with 1N hydrochloric acid solution and extracted with ethyl acetate. The residue obtained is then purified by chromatography (eluent: 9/1 heptane/ethyl acetate). A white solid is obtained (m=16.5 g; yield=67%; m.p.=144° C.).

1. temperatureThe mixture is warmed to room temperature
2. extractionextracted with ethyl acetate
3. customThe residue obtained
4. customis then purified by chromatography (eluent: 9/1 heptane/ethyl acetate)
5. customA white solid is obtained (m=16.5 g; yield=67%; m.p.=144° C.)