反应详情

温度

65 °C

A mixture of 5-Iodo-benzene-1,3-diol (2 g, 8 mmol), 2-bromopropane (0.88 mL, 9.3 mmol) and potassium carbonate (1.3 g, 9.3 mmol) in DMF (15 mL, 190 mmol) was stirred at 65° C. After 18 h, the mixture was cooled to RT and the solvent was evaporated. The residue was dissolved in DCM, washed with water and brine. The solvent was evaporated and the residue was purified on silica gel using an ISCO instrument and eluting with hexanes:EtOAc (4:1) to afford the title product (841 mg). MS m/z: 279 [M+H]+.

1. temperaturethe mixture was cooled to RT
2. customthe solvent was evaporated
3. dissolutionThe residue was dissolved in DCM
4. washwashed with water and brine
5. customThe solvent was evaporated
6. customthe residue was purified on silica gel using an ISCO instrument
7. washeluting with hexanes:EtOAc (4:1)