反应详情

温度

0 °C

Sodium hydride (60% in mineral oil; 1.45 g) was added portionwise over 10 min to a solution of ethyl acetoacetate (4.4 mL) in THF (60 mL) at 0° C. The resulting suspension was stirred at 0° C. for 10 min and a solution of methyl 4-(bromomethyl)-3-methoxybenzoate (7.5 g) in THF (40 mL) added portionwise over 10 min. The mixture was warmed to 70° C. and stirred for 15 h. The mixture was allowed to cool and then poured cautiously into ice/water (300 mL) and stirred for 30 min. The aqueous phase was extracted with EtOAc and the combined organic phase was dried filtered and evaporated to afford crude product. The reaction was repeated on an identical scale and the two batches of crude product were combined and purified by chromatography eluting with 20-30% EtOAc in isohexane to give the subtitle compound as a colorless oil 14.70 g.

1. temperatureThe mixture was warmed to 70° C.
2. stirringstirred for 15 h
3. temperatureto cool
4. stirringstirred for 30 min
5. extractionThe aqueous phase was extracted with EtOAc
6. customthe combined organic phase was dried
7. filtrationfiltered
8. customevaporated
9. customto afford crude product
10. custompurified by chromatography
11. washeluting with 20-30% EtOAc in isohexane