反应详情

A stirred mixture of methyl 3-hydroxy-2-methylenebutanoate (11.37 ml), 2-(3-bromophenyl)acetonitrile (22 g) PdOAc2 (3.15 g), tetrabutylammonium bromide (30.1 g) and NaHCO3 (19.64 g) in THF (40 ml) was heated at reflux for 24 h. The mixture was partitioned between ether and water, the organics separated, washed with water, dried and evaporated under reduced pressure to give the subtitle compound, 22 g.

1. temperaturewas heated
2. temperatureat reflux for 24 h
3. customThe mixture was partitioned between ether and water
4. washthe organics separated, washed with water
5. customdried
6. customevaporated under reduced pressure