Hydrochloric Acid → HCID 86688554, compound

HRID 1617319Notes

Reaction equation

HRID 1617319 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:15]=[N:16][C:17]([O:20][CH2:21][CH3:22])=[CH:18][CH:19]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:23]>CCOC(C)=O>[ClH:23].[CH2:21]([O:20][C:17]1[N:16]=[CH:15][C:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[CH:19][CH:18]=1)[CH3:22]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86688555HCID 86688555, compound

Product 1

HCID 86688554HCID 86688554, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To 4.30 g (13.9 mmol) 6-Ethoxy-3′,4′,5′,6′-tetrahydro-2′H-[3,4]bipyridinyl-1′-carboxylic acid tert-butyl ester (VII.1) in 10 mL EtOAc are added 120 mL 4N HCl in EtOAc. The mixture is stirred for 12 h at rt. After that time, the solvent is evaporated to yield the desired product.

Workup

  1. customAfter that time, the solvent is evaporated

Sources & evidence

ORD record
ord-80063d9005364dac9583896e9df615b0
Source dataset
uspto-grants-2014_07
Patent number
US08765959B2

Reaction notes

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