Hydroxyamine hydrochloride → HCID 136359962, compound

HRID 1617444Notes

Reaction equation

HRID 1617444 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH3:24])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=O)[CH:5]=[CH:6][CH:7]=1.Cl.[NH2:26][OH:27].C([O-])(O)=O.[Na+]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH3:24])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[N:26][OH:27])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66667109HCID 66667109, compound

Product 1

HCID 136359962HCID 136359962, compound

Procedure

In analogy to example 1, step 2, from 3-(3-bromo-phenyl)-3-o-tolyl-1-pyridin-4-yl-propan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a mixture of E and Z isomers (3:1) as a white foam, MS (ESI+): m/z=395.0 ([M+H]+, 1Br).

Sources & evidence

ORD record
ord-4912369654db43a8abc5e440c90e1256
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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