Hydroxyamine hydrochloride → HCID 136359964, compound

HRID 1617451Notes

Reaction equation

HRID 1617451 reaction equation
[CH3:1][N:2]([CH3:27])[C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:19]2[CH:24]=[C:23]([CH3:25])[CH:22]=[C:21]([CH3:26])[CH:20]=2)[CH2:10][C:11]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=O)=[CH:5][CH:4]=1.Cl.[NH2:29][OH:30].C([O-])(O)=O.[Na+]>>[CH3:1][N:2]([CH3:27])[C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:19]2[CH:24]=[C:23]([CH3:25])[CH:22]=[C:21]([CH3:26])[CH:20]=2)[CH2:10][C:11]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[N:29][OH:30])=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66668607HCID 66668607, compound

Product 1

HCID 136359964HCID 136359964, compound

Procedure

In analogy to example 1, step 2, from 3-(4-dimethylamino-phenyl)-3-(3,5-dimethyl-phenyl)-1-pyridin-4-yl-propan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a mixture of E and Z isomers (2.9:1) as a light yellow foam, MS (ESI+): m/z=374.3 ([M+H]+).

Sources & evidence

ORD record
ord-8f03ca6c778c40e0a685f20c0c90deac
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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