Hydroxyamine hydrochloride → HCID 136359968, compound

HRID 1617463Notes

Reaction equation

HRID 1617463 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH3:24])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=O)=[CH:4][CH:3]=1.Cl.[NH2:26][OH:27].C([O-])(O)=O.[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH3:24])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[N:26][OH:27])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66666379HCID 66666379, compound

Product 1

HCID 136359968HCID 136359968, compound

Procedure

In analogy to example 1, step 2, from 3-(4-bromo-phenyl)-1-pyridin-4-yl-3-o-tolyl-propan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a mixture of E and Z isomers (2.5:1) as a white foam, MS (ESI+): m/z=395.1 ([M+H]+, 1Br).

Sources & evidence

ORD record
ord-b49f9122a6d04a6996fdd65295177f57
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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