Hydroxyamine hydrochloride → HCID 136359973, compound

HRID 1617472Notes

Reaction equation

HRID 1617472 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([Cl:18])[CH:13]=2)=O)=[CH:4][CH:3]=1.Cl.[NH2:26][OH:27].C([O-])(O)=O.[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([Cl:18])[CH:13]=2)=[N:26][OH:27])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 86660936HCID 86660936, compound

Product 1

HCID 136359973HCID 136359973, compound

Procedure

In analogy to example 1, step 2, from 3-(4-bromo-phenyl)-1-(2-chloro-pyridin-4-yl)-3-phenyl-propan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a mixture of E and Z isomers (2.6:1) as a colorless oil, MS (ESI−): m/z=413.0 ([M−H]−, 1Br,1Cl).

Sources & evidence

ORD record
ord-2abf58cce9724dcea7b4c5965717b647
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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