Phenylboronic Acid → HCID 87237114, compound

HRID 1617473Notes

Reaction equation

[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[Cl:10][C:11]1[CH:16]=[C:15]([C:17](=[O:19])[CH3:18])[CH:14]=[C:13]([Cl:20])[N:12]=1.[C:21]1(B(O)O)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:18][C:17]([C:15]2[CH:14]=[C:13]([Cl:20])[N:12]=[C:11]([Cl:10])[CH:16]=2)=[O:19])=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 66827Phenylboronic Acid

HCID 707414-Bromobenzaldehyde

HCID 221194461-(2,6-Dichloropyridin-4-YL)ethanone

Product 1

HCID 87237114HCID 87237114, compound

Procedure

In analogy to example 11, step 1, from 4-bromobenzaldehyde and 1-[2,6-dichloropyridin-4-yl]ethanone (CAS RN: [185319-20-4]) was prepared 3-(4-bromo-phenyl)-1-(2,6-dichloro-pyridin-4-yl)-propenone as a yellow solid, which was directly subjected to the next step. In analogy to example 1, step 1, from 3-(4-bromo-phenyl)-1-(2,6-dichloro-pyridin-4-yl)-propenone and phenylboronic acid was prepared the title compound as a colorless oil, MS (EI+): m/z=433 ([M]+, 1Br, 1Cl).

Sources & evidence

ORD record: ord-bd8d375d5c224950a8d470938ddf92e3
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

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