Hydroxyamine hydrochloride → HCID 76671396, compound

HRID 1617475Notes

Reaction equation

HRID 1617475 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[CH3:26])[CH2:9][C:10]([C:12]2[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:13]=2[Cl:19])=O)=[CH:4][CH:3]=1.Cl.[NH2:28][OH:29].C([O-])(O)=O.[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[CH3:26])[CH2:9][C:10]([C:12]2[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:13]=2[Cl:19])=[N:28][OH:29])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66668679HCID 66668679, compound

Product 1

HCID 76671396HCID 76671396, compound

Procedure

In analogy to example 1, step 2, from 3-(4-bromo-phenyl)-1-(2,5-dichloro-phenyl)-3-o-tolyl-propan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a mixture of E and Z isomers (2.4:1) as a white foam, MS (EI): m/z=463 ([M]+, 1Br).

Sources & evidence

ORD record
ord-3107b2d16ab44d5291e4dd86c3a66fc9
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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