Hydroxyamine hydrochloride → HCID 136359992, compound

HRID 1617521Notes

Reaction equation

[CH3:1][C:2]1[CH:7]=[C:6]([C:8](=O)[CH2:9][CH:10]([C:18]2[CH:23]=[CH:22][C:21]([CH:24]=[CH:25][C:26]([OH:28])=[O:27])=[CH:20][CH:19]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])[CH:5]=[CH:4][N:3]=1.Cl.[NH2:31][OH:32].C([O-])(O)=O.[Na+]>>[OH:32][N:31]=[C:8]([C:6]1[CH:5]=[CH:4][N:3]=[C:2]([CH3:1])[CH:7]=1)[CH2:9][CH:10]([C:18]1[CH:23]=[CH:22][C:21]([CH:24]=[CH:25][C:26]([OH:28])=[O:27])=[CH:20][CH:19]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH3:17]

Participants

Reactant 3

HCID 443297Hydroxyamine hydrochloride

HCID 516892Sodium Bicarbonate

HCID 67015515HCID 67015515, compound

Product 1

HCID 136359992HCID 136359992, compound

Procedure

In analogy to example 74, step 7, from 3-{4-[3-(2-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-phenyl}-acrylic acid and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a mixture of Z to E isomers (1.7:1) as a colorless oil, MS (ESI+): m/z=401.1859 ([M+H]+).

Sources & evidence

ORD record: ord-8b52525f83454d09a8f050e872242684
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

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