Hydroxyamine hydrochloride → HCID 136359997, compound

HRID 1617531Notes

Reaction equation

HRID 1617531 reaction equation
[C:1]1([C@H:7]([NH:9][C:10]([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][C:21]([C@@H:24]([C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=4[CH3:41])[CH2:25][C:26]([C:28]4[CH:33]=[CH:32][N:31]=[C:30]([CH3:34])[CH:29]=4)=O)=[CH:20][CH:19]=3)=[CH:14][CH:13]=2)=[O:11])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:43][OH:44].C([O-])(O)=O.[Na+]>>[C:1]1([C@H:7]([NH:9][C:10]([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][C:21]([C@@H:24]([C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=4[CH3:41])[CH2:25][C:26](=[N:43][OH:44])[C:28]4[CH:33]=[CH:32][N:31]=[C:30]([CH3:34])[CH:29]=4)=[CH:20][CH:19]=3)=[CH:14][CH:13]=2)=[O:11])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 67015528HCID 67015528, compound

Product 1

HCID 136359997HCID 136359997, compound

Procedure

In analogy to example example 74, step 7, from 4′-[(S)-3-(2-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-biphenyl-4-carboxylic acid ((R)-1-phenyl-ethyl)-amide and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a mixture of E and Z isomers (3.4:1) as a colorless oil, MS (ESI+): m/z=553.702 ([M+H]+).

Sources & evidence

ORD record
ord-42f05074276c46f292f60f581f082dd7
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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