Hydroxyamine hydrochloride → HCID 136360003, compound

HRID 1617548Notes

Reaction equation

HRID 1617548 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:6]=[C:7]([CH:11]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[CH3:28])[CH2:12][C:13]([C:15]2[CH:20]=[CH:19][N:18]=[C:17]([CH3:21])[CH:16]=2)=O)[CH:8]=[CH:9][CH:10]=1.Cl.[NH2:30][OH:31].C([O-])(O)=O.[Na+]>>[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:6]=[C:7]([CH:11]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[CH3:28])[CH2:12][C:13]([C:15]2[CH:20]=[CH:19][N:18]=[C:17]([CH3:21])[CH:16]=2)=[N:30][OH:31])[CH:8]=[CH:9][CH:10]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66665958HCID 66665958, compound

Product 1

HCID 136360003HCID 136360003, compound

Procedure

In analogy to example 74, step 7, from 3-[3-(3-hydroxy-propyl)-phenyl]-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a mixture of E and Z isomers (3:1) as a colorless oil, MS (ESI+): m/z=389.2 ([M+H]+).

Sources & evidence

ORD record
ord-daf6516a96124f0180baa922b45000bf
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

Loading…