Hydroxyamine hydrochloride → HCID 136360008, compound

HRID 1617561Notes

Reaction equation

HRID 1617561 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:18][CH:19]([CH3:21])[CH3:20])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=O)=[CH:4][CH:3]=1.Cl.[NH2:23][OH:24].C([O-])(O)=O.[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:18][CH:19]([CH3:21])[CH3:20])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[N:23][OH:24])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66666829HCID 66666829, compound

Product 1

HCID 136360008HCID 136360008, compound

Procedure

In analogy to example 74, step 7, from 3-(4-bromo-phenyl)-5-methyl-1-pyridin-4-yl-hexan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a mixture of E and Z isomers (2.7:1) as a colorless oil, MS (ESI+): m/z=361.2 ([M+H]+, 1Br).

Sources & evidence

ORD record
ord-4cbee3335b9544efaf30a40069b08dfb
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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