Hydroxyamine hydrochloride → HCID 136360015, compound

HRID 1617580Notes

Reaction equation

HRID 1617580 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:9][C:10]([C:12]2[C:17](C)=[CH:16][N:15]=[C:14](F)[CH:13]=2)=O)=[CH:4][CH:3]=1.Cl.[NH2:25][OH:26].[C:27]([O-])(O)=O.[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH3:27])[CH:13]=2)=[N:25][OH:26])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 67015572HCID 67015572, compound

Product 1

HCID 136360015HCID 136360015, compound

Procedure

In analogy to example 74, step 7, from 3-(4-bromo-phenyl)-1-(2-fluoro-5-methyl-pyridin-4-yl)-4,4-dimethyl-pentan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a mixture of E and Z isomers (3.7:1) as a white foam, MS (ESI+): m/z=375.1062 ([M+H]+, 1Br).

Sources & evidence

ORD record
ord-d4a47c2bc40842f39a5a95038ca7da4f
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

Loading…