Hydroxyamine hydrochloride → HCID 136166981, compound

HRID 1617618Notes

Reaction equation

HRID 1617618 reaction equation
[CH3:1][CH:2]([CH:11]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:3]([C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)=O.Cl.[NH2:25][OH:26].C([O-])(O)=O.[Na+]>>[CH3:1][CH:2]([CH:11]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)/[C:3](/[C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)=[N:25]\[OH:26]

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66669058HCID 66669058, compound

Product 1

HCID 136166981HCID 136166981, compound

Procedure

In analogy to example 151, step 3, 2-methyl-3,3-diphenyl-1-pyridin-4-yl-propan-1-one was reacted with hydroxylamine hydrochloride in the presence of NaHCO3 to give the title compound as an off-white solid, MS (ESI+): m/z=317.16 [M+H]+.

Sources & evidence

ORD record
ord-6444f2fdf4294ee496a049b98781fce9
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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