Hydroxyamine hydrochloride → HCID 58043612, compound

HRID 1617654Notes

Reaction equation

HRID 1617654 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:20][CH2:21][CH2:22][C:23]([F:26])([F:25])[F:24])[CH2:9][C:10]([C:12]2[CH:13]=[CH:14][C:15](=[O:19])[N:16]([CH3:18])[CH:17]=2)=O)=[CH:4][CH:3]=1.Cl.[NH2:28][OH:29].C([O-])(O)=O.[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:20][CH2:21][CH2:22][C:23]([F:26])([F:25])[F:24])[CH2:9]/[C:10](/[C:12]2[CH:13]=[CH:14][C:15](=[O:19])[N:16]([CH3:18])[CH:17]=2)=[N:28]\[OH:29])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 67015531HCID 67015531, compound

Product 1

HCID 58043612HCID 58043612, compound

Procedure

In analogy to example 151, step 3, 5-[3-(4-bromo-phenyl)-7,7,7-trifluoro-heptanoyl]-1-methyl-1H-pyridin-2-one was reacted with hydroxylamine hydrochloride in the presence of NaHCO3 to give the title compound containing 14% of the corresponding Z isomer as a colorless solid, MS (ESI+): m/z=445.3 [M+H]+.

Sources & evidence

ORD record
ord-59f085b4e4964085a1d034d533ea2524
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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