Ethanol → HCID 87237018, compound

HRID 1617716Notes

Reaction equation

HRID 1617716 reaction equation
[CH3:1][N:2]1[C:7](=[O:8])[CH:6]=[CH:5][C:4]([C:9](=O)[CH2:10][CH:11]([C:19]2[CH:33]=[CH:32][C:22]([C:23]([NH:25][CH2:26][CH2:27][CH2:28][C:29](O)=[O:30])=[O:24])=[CH:21][CH:20]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])=[CH:3]1.Cl.[NH2:36][OH:37].C([O-])(O)=O.[Na+].[CH2:43]([OH:45])[CH3:44]>O>[CH2:43]([O:45][C:29](=[O:30])[CH2:28][CH2:27][CH2:26][NH:25][C:23](=[O:24])[C:22]1[CH:21]=[CH:20][C:19]([CH:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])[CH2:10]/[C:9](=[N:36]\[OH:37])/[C:4]2[CH:5]=[CH:6][C:7](=[O:8])[N:2]([CH3:1])[CH:3]=2)=[CH:33][CH:32]=1)[CH3:44]

Participants

6

Reactant 4

HCID 702EthanolHCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 67015650HCID 67015650, compound

Product 1

HCID 87237018HCID 87237018, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In analogy to example 151, step 3, 4-{4-[3-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-3-oxo-1-o-tolyl-propyl]-benzoylamino}-butyric acid was reacted with hydroxylamine hydrochloride in ethanol and water in the presence of NaHCO3 to give the title compound as a colorless solid, MS (ESI+): m/z=504.3 [M+H]+.

Sources & evidence

ORD record
ord-986c559f337f4c0c9b55bdaca5fd9f2c
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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