Hydroxyamine hydrochloride → HCID 87237054, compound

HRID 1617773Notes

Reaction equation

HRID 1617773 reaction equation
[C:1]([NH:4][CH2:5][CH2:6][NH:7][C:8](=[O:34])[C:9]1[CH:14]=[CH:13][C:12]([CH:15]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[CH3:33])[CH2:16][C:17]([C:19]2[CH:24]=[CH:23][C:22](=[O:25])[N:21]([CH3:26])[CH:20]=2)=O)=[CH:11][CH:10]=1)(=[O:3])[CH3:2].Cl.[NH2:36][OH:37].C([O-])(O)=O.[Na+]>>[C:1]([NH:4][CH2:5][CH2:6][NH:7][C:8](=[O:34])[C:9]1[CH:14]=[CH:13][C:12]([CH:15]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[CH3:33])[CH2:16]/[C:17](=[N:36]\[OH:37])/[C:19]2[CH:24]=[CH:23][C:22](=[O:25])[N:21]([CH3:26])[CH:20]=2)=[CH:11][CH:10]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 67015600HCID 67015600, compound

Product 1

HCID 87237054HCID 87237054, compound

Procedure

In analogy to example 151, step 3, N-(2-acetylamino-ethyl)-4-[3-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-3-oxo-1-o-tolyl-propyl]-benzamide was reacted with hydroxylamine hydrochloride in the presence of NaHCO3 to give the title compound containing less than 10% of the corresponding Z isomer as a colorless solid, MS (ESI+): m/z=475.2 [M+H]+.

Sources & evidence

ORD record
ord-c6ae02ce1b144bfcb3d6096ac5f7e267
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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