Hydroxyamine hydrochloride → HCID 136166976, compound

HRID 1617805Notes

Reaction equation

HRID 1617805 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8](=O)[CH2:9][C@H:10]([C:18]2[CH:23]=[CH:22][C:21]([N:24]3[CH2:27][CH:26]([C:28]([OH:30])=[O:29])[CH2:25]3)=[CH:20][CH:19]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])[CH:5]=[CH:4][N:3]=1.[ClH:32].[NH2:33][OH:34].C(=O)([O-])O.[Na+]>>[Cl:32][CH2:27][CH:26]([CH2:25][NH:24][C:21]1[CH:22]=[CH:23][C:18]([C@H:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])[CH2:9]/[C:8](=[N:33]\[OH:34])/[C:6]2[CH:5]=[CH:4][N:3]=[C:2]([CH3:1])[CH:7]=2)=[CH:19][CH:20]=1)[C:28]([OH:30])=[O:29]

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66666620HCID 66666620, compound

Product 1

HCID 136166976HCID 136166976, compound

Procedure

In analogy to example 132, step 6, from 1-{4-[(R)-3-(2-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-phenyl}-azetidine-3-carboxylic acid (example 279, step 1) and hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate was prepared the title compound as a yellow foam, MS (ESI+): m/z=466.2 ([M+H]+).

Sources & evidence

ORD record
ord-9083d78d30fe48788219fb9a8e54530b
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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