Hydroxyamine hydrochloride → HCID 136166865, compound

HRID 1617812Notes

Reaction equation

HRID 1617812 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([C:19]2[CH:24]=[CH:23][C:22]([N:25]3[CH2:30][CH2:29][CH:28](C(O)=O)[CH2:27][CH2:26]3)=[CH:21][CH:20]=2)[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH3:18])[CH:13]=2)=O)=[C:4]([CH3:34])[CH:3]=1.Cl.[NH2:36][OH:37].[C:38](=[O:41])([O-])[OH:39].[Na+]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([C:19]2[CH:20]=[CH:21][C:22]([N:25]3[CH2:30][CH2:29][CH:28]([C:38]([OH:39])=[O:41])[CH2:27][CH2:26]3)=[CH:23][CH:24]=2)[CH2:9]/[C:10](=[N:36]\[OH:37])/[C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH3:18])[CH:13]=2)=[C:4]([CH3:34])[CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66666451HCID 66666451, compound

Product 1

HCID 136166865HCID 136166865, compound

Procedure

In analogy to example 132, step 6, from 1-{4-[(S)-1-(4-chloro-2-methyl-phenyl)-3-(2-methyl-pyridin-4-yl)-3-oxo-propyl]-phenyl}-piperidine-4-carboxylic acid and hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate was prepared the title compound as a light yellow foam, MS (ESI−): m/z=490.3 ([M−H]−).

Sources & evidence

ORD record
ord-12cea1d9782443a893a62e465c4abf56
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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