Hydroxyamine hydrochloride → HCID 58043620, compound

HRID 1617937Notes

Reaction equation

HRID 1617937 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:36]=[CH:35][C:23]([O:24][C:25]3[CH:26]=[CH:27][C:28]([F:34])=[C:29]([CH:33]=3)[C:30]([OH:32])=[O:31])=[CH:22][CH:21]=2)[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][C:15](=[O:18])[N:14]([CH3:19])[CH:13]=2)=O)=[C:4]([CH3:37])[CH:3]=1.Cl.[NH2:39][OH:40].C(=O)([O-])O.[Na+]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:36]=[CH:35][C:23]([O:24][C:25]3[CH:26]=[CH:27][C:28]([F:34])=[C:29]([CH:33]=3)[C:30]([OH:32])=[O:31])=[CH:22][CH:21]=2)[CH2:9]/[C:10](=[N:39]\[OH:40])/[C:12]2[CH:17]=[CH:16][C:15](=[O:18])[N:14]([CH3:19])[CH:13]=2)=[C:4]([CH3:37])[CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66668714HCID 66668714, compound

Product 1

HCID 58043620HCID 58043620, compound

Procedure

In analogy to example 151, step 3, 5-{4-[1-(4-chloro-2-methyl-phenyl)-3-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-3-oxo-propyl]-phenoxy}-2-fluoro-benzoic acid was reacted with hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate to give the title compound as a colourless solid, MS (ESI−): m/z=533.1 [M−H]−.

Sources & evidence

ORD record
ord-106845b22c514d159154a8baee240187
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

Loading…