Hydroxyamine hydrochloride → HCID 58043604, compound

HRID 1617959Notes

Reaction equation

HRID 1617959 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:25]=[CH:24][C:23]([N:26]3[CH2:30][CH2:29][CH2:28][C:27]3=[O:31])=[CH:22][CH:21]=2)[CH2:9][C:10]([C:12]2[CH:13]=[CH:14][C:15](=[O:19])[N:16]([CH3:18])[CH:17]=2)=O)=[C:4]([CH3:32])[CH:3]=1.Cl.[NH2:34][OH:35].C(=O)([O-])O.[Na+]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:21]=[CH:22][C:23]([N:26]3[CH2:30][CH2:29][CH2:28][C:27]3=[O:31])=[CH:24][CH:25]=2)[CH2:9]/[C:10](/[C:12]2[CH:13]=[CH:14][C:15](=[O:19])[N:16]([CH3:18])[CH:17]=2)=[N:34]\[OH:35])=[C:4]([CH3:32])[CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 67015684HCID 67015684, compound

Product 1

HCID 58043604HCID 58043604, compound

Procedure

In analogy to example 151, step 3, 5-{3-(4-chloro-2-methyl-phenyl)-3-[4-(2-oxo-pyrrolidin-1-yl)-phenyl]-propionyl}-1-methyl-1H-pyridin-2-one was reacted with hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate to give the title compound containing less than 10% of the corresponding Z isomer as a colourless solid, MS (ESI+): m/z=464.2 [M+H]+.

Sources & evidence

ORD record
ord-9dc7361adaa64dc99c60e418dc5c93ef
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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