Hydroxyamine hydrochloride → HCID 136167065, compound

HRID 1617994Notes

Reaction equation

HRID 1617994 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][C:21]=2[CH3:27])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][OH:19])[CH:13]=2)=O)=[CH:4][CH:3]=1.Cl.[OH:29][NH2:30].C(=O)([O-])O.[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][C:21]=2[CH3:27])[CH2:9]/[C:10](/[C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][OH:19])[CH:13]=2)=[N:30]\[OH:29])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 67015691HCID 67015691, compound

Product 1

HCID 136167065HCID 136167065, compound

Procedure

In analogy to example 132, step 6, from (R)-3-(4-bromophenyl)-3-(4-chloro-2-methyl-phenyl)-1-(2-(hydroxymethyl)pyridin-4-yl)propan-1-one (example 282, step 1) and hydroxyl-amine hydrochloride in the presence of sodium hydrogencarbonate was prepared the title compound as a white foam, MS (ESI+): m/z=459.2 ([M+H]+).

Sources & evidence

ORD record
ord-4a553661b2e14912a36fa7f06724132d
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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