Hydroxyamine hydrochloride → HCID 136167059, compound

HRID 1618057Notes

Reaction equation

[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:15]=[CH:14][C:13]([C@H:16]([C:27]3[CH:32]=[CH:31][C:30](Cl)=[CH:29][C:28]=3[CH3:34])[CH2:17][C:18]([C:20]3[CH:25]=[CH:24][N:23]=[C:22]([CH3:26])[CH:21]=3)=O)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[ClH:35].[NH2:36][OH:37].C(=O)([O-])O.[Na+]>>[Cl:35][C:30]1[CH:31]=[CH:32][C:27]([C@@H:16]([C:13]2[CH:14]=[CH:15][C:10]([CH:7]3[CH2:8][CH2:9][N:4]([C:1](=[O:3])[CH3:2])[CH2:5][CH2:6]3)=[CH:11][CH:12]=2)[CH2:17]/[C:18](=[N:36]\[OH:37])/[C:20]2[CH:25]=[CH:24][N:23]=[C:22]([CH3:26])[CH:21]=2)=[C:28]([CH3:34])[CH:29]=1

Participants

Reactant 3

HCID 443297Hydroxyamine hydrochloride

HCID 516892Sodium Bicarbonate

HCID 66667137HCID 66667137, compound

Product 1

HCID 136167059HCID 136167059, compound

Procedure

In analogy to example 132, step 6, from (R)-3-(4-(1-acetylpiperidin-4-yl)phenyl)-3-(4-chloro-2-methylphenyl)-1-(2-methylpyridin-4-yl)propan-1-one and hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate was prepared the title compound as a white foam, MS (ESI+): m/z=490.0 [M+H]+.

Sources & evidence

ORD record: ord-441422470eaa46cc8b79aac85aba2443
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

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