Hydrochloric Acid → HCID 86673626, compound

HRID 1618892Notes

Reaction equation

HRID 1618892 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:18](=O)[CH3:19])[CH:2]=1.Cl.[NH2:22][OH:23].Cl>N1C=CC=CC=1>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:18](=[N:22][OH:23])[CH3:19])[CH:2]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 443297Hydroxyamine hydrochlorideHCID 68285598HCID 68285598, compound

Product 1

HCID 86673626HCID 86673626, compoundYield 111.1%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

0.46 g of 1-[2-(quinolin-3-yloxy)-phenyl]-ethanone and 0.15 g of hydroxylamine hydrochloride were dissolved in 3 ml of pyridine and then the mixture was stirred for 24 hours at room temperature. After the reaction mixture was treated with dilute hydrochloric acid and separated with ethyl acetate, the organic layer was concentrated to obtain 0.54 g of 1-[2-(quinolin-3-yloxy)-phenyl]-ethanone oxime (Compound Number 23).

Workup

  1. customseparated with ethyl acetate
  2. concentrationthe organic layer was concentrated

Sources & evidence

ORD record
ord-03a2ef0a39264b7aa968e6684263b5bb
Source dataset
uspto-grants-2014_07
Patent number
US08772200B2

Reaction notes

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