反应详情

温度

30 °C

To a suspension of NaH (54 gm, 1.11 moles) in dry THF (500 ml) a solution of ethyl 2-(4-(benzyloxy)phenyl)acetate (100 gm, 0.37 moles) in dry THF (100 ml) was added at 0° C. To this was added diethyl carbonate (180 ml, 1.48 mole) dropwise over a period of one hour maintaining the reaction temperature at below 5° C. The reaction mixture was then stirred for 18 hours at 30° C. The contents of the reaction mixture were poured into ice cold water and extracted with ethyl acetate. The organic extract was successively washed with water & brine, dried over sodium sulfate and evaporated under reduced pressure to yield 100 gm of product as white solid.

1. additionwas added at 0° C
2. temperaturemaintaining the reaction temperature at below 5° C
3. additionThe contents of the reaction mixture were poured into ice cold water
4. extractionextracted with ethyl acetate
5. extractionThe organic extract
6. washwas successively washed with water & brine
7. dry with materialdried over sodium sulfate
8. customevaporated under reduced pressure