Piperidine → HCID 67464358, compound

HRID 1619921Notes

Reaction equation

HRID 1619921 reaction equation
[Br:1][C:2]1[CH:18]=[CH:17][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13][C:12]([CH2:15]Br)=[CH:11][CH:10]=3)[O:8][C:4]=2[CH:3]=1.[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>C1COCC1>[Br:1][C:2]1[CH:18]=[CH:17][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13][C:12]([CH2:15][N:19]4[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]4)=[CH:11][CH:10]=3)[O:8][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 67466145HCID 67466145, compound

Product 1

HCID 67464358HCID 67464358, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

200 mg (545 μmol) 6-bromo-2-(4-bromomethyl-phenyl)-benzoxazole and 100 mg (1174 μmol) piperidine are stirred for 20 min in 4 ml THF at RT, the solv. is eliminated by rotary evaporation in vacuo. The residue is dissolved in ether and extracted with water, the org. phase is dried on magnesium sulphate and the solv. is eliminated completely in vacuo.

Workup

  1. customis eliminated by rotary evaporation in vacuo
  2. dissolutionThe residue is dissolved in ether
  3. extractionextracted with water
  4. customphase is dried on magnesium sulphate

Sources & evidence

ORD record
ord-b43d6901751741d89b846ebe1dbe158e
Source dataset
uspto-grants-2014_07
Patent number
US08772323B2

Reaction notes

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