Hydrochloric Acid → HCID 67466209, compound

HRID 1619947Notes

Reaction equation

HRID 1619947 reaction equation
[CH3:1][CH:2]([CH3:26])[CH:3]([C:9]([C:11]1[CH:25]=[CH:24][C:14]2[N:15]=[C:16]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[O:17][C:13]=2[CH:12]=1)=[O:10])[CH2:4][C:5]([O:7]C)=[O:6].[OH-].[Li+].O.Cl>O1CCOCC1>[CH3:1][CH:2]([CH3:26])[CH:3]([C:9]([C:11]1[CH:25]=[CH:24][C:14]2[N:15]=[C:16]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[O:17][C:13]=2[CH:12]=1)=[O:10])[CH2:4][C:5]([OH:7])=[O:6]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 67465972HCID 67465972, compound

Product 1

HCID 67466209HCID 67466209, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

100 mg (285 μmol) methyl 4-methyl-3-(2-phenyl-benzoxazole-6-carbonyl)-pentanoate, 10 mg (418 μmol) lithium hydroxide, 1 ml of water and 1 ml dioxane are stirred for 24 h at RT. The reaction mixture is acidified with conc. hydrochloric acid and extracted with diethyl ether, the org. phase is dried on magnesium sulphate and the solv. is eliminated by rotary evaporation i.V.

Workup

  1. extractionextracted with diethyl ether
  2. customphase is dried on magnesium sulphate

Sources & evidence

ORD record
ord-d0498a0cfb034f8e8d2ea3cd979c56ac
Source dataset
uspto-grants-2014_07
Patent number
US08772323B2

Reaction notes

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