Bis(2-Methoxyethyl)amine → HCID 260177, compound

HRID 1620068Notes

Reaction equation

HRID 1620068 reaction equation
C(=O)([O-])[O-].[K+].[K+].[CH3:7][O:8][CH2:9][CH2:10][NH:11][CH2:12][CH2:13][O:14][CH3:15].CN(C=O)C.Cl[C:22]1[CH:27]=[CH:26][C:25]([N+:28]([O-:30])=[O:29])=[CH:24][N:23]=1>O>[CH3:7][O:8][CH2:9][CH2:10][N:11]([CH2:12][CH2:13][O:14][CH3:15])[C:22]1[CH:27]=[CH:26][C:25]([N+:28]([O-:30])=[O:29])=[CH:24][N:23]=1

Participants

6

Reactant 4

HCID 2383Bis(2-Methoxyethyl)amineHCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 783082-Chloro-5-nitropyridine

Product 1

HCID 260177HCID 260177, compoundYield 72.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Potassium carbonate (262 mg) and bis(2-methoxyethyl)amine (840 mg) were added to a DMF (2 ml) solution containing 2-chloro-5-nitropyridine (100 mg), followed by stirring at room temperature for 5 hours. Water (15 ml) was added to the reaction solution, followed by stirring at room temperature for 1 hour. Insoluble matter was collected by filtration, and a white solid of N,N-bis(2-methoxyethyl)-5-nitropyridin-2-amine (117 mg) was thus obtained.

Workup

  1. stirringby stirring at room temperature for 1 hour
  2. filtrationInsoluble matter was collected by filtration

Sources & evidence

ORD record
ord-9c2b8df4827e430ea9c0ff519ca50b3e
Source dataset
uspto-grants-2014_07
Patent number
US08772320B2

Reaction notes

Loading…