Hydrochloric Acid → Dopamine

HRID 1622035Notes

Reaction equation

HRID 1622035 reaction equation
OP([O-])(O)=O.OP([O-])([O-])=O.[Na+].[Na+].[Na+].[Cl-].[Cl-].[K+].[K+].Cl.Cl.C(N=C=NCCCN(C)C)C.Cl.[NH2:32][CH2:33][CH2:34][C:35]1[CH:42]=[CH:41][C:39]([OH:40])=[C:37]([OH:38])[CH:36]=1>CC(C)=O>[NH2:32][CH2:33][CH2:34][C:35]1[CH:42]=[CH:41][C:39]([OH:40])=[C:37]([OH:38])[CH:36]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 65340Dopamine HydrochlorideHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 24978514Phosphate Buffered Saline

Product 1

HCID 681DopamineYield 90%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The CNT obtained in Manufacturing Example 2 was added to a solvent mixture of phosphate buffered saline (“PBS”) and acetone mixed in the ratio of 1:1 to have a concentration of 0.5 milligrams per milliliter (mg/ml) and then 1 M of hydrogen chloride (HCl) was used to adjust the acidity of the mixture to a pH of 5.5. Here, 147.5 mg of 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride and 145.9 mg of dopamine hydrochloride were added to the mixture and mixed for about 4 hours. After completing the mixing, the resulting CNT was separated from the mixture using a 0.2 μm polycarbonate filter and then was dried, thereby obtaining a composite having a yield of 90 percent (%).

Workup

  1. customThe CNT obtained in Manufacturing Example 2
  2. additionmixed in the ratio of 1:1
  3. additionmixed for about 4 hours
  4. customthe resulting CNT was separated from the mixture
  5. filtrationfilter
  6. customwas dried
  7. customobtaining

Sources & evidence

ORD record
ord-b308fa6570c94f91bc7c1ff82f00c9f4
Source dataset
uspto-grants-2014_07
Patent number
US08778296B2

Reaction notes

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