反应详情

温度

120 °C

Potassium carbonate (18.53 mg) was added to a mixture of 3-phenoxyazetidine (20 mg) and 3-bromo-5-methylpyrazin-2-amine (25 mg) in DMF (dry) (1 mL). The mixture was stirred at 120° C. for 4 hr. Water and EtOAc were added and the extracted organic layer was washed with brine, dried over anhydrous sodium sulfate and concentrated in vacuo. The residue was purified by column chromatography (silica gel, eluted with EtOAc in hexane) to give the title compound (12 mg) as white solid.

1. washthe extracted organic layer was washed with brine
2. dry with materialdried over anhydrous sodium sulfate
3. concentrationconcentrated in vacuo
4. customThe residue was purified by column chromatography (silica gel, eluted with EtOAc in hexane)